Development and survival of lymphocyte &Adaptive immune response

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Development and survival of lymphocyte &Adaptive immune response

Development and survival of lymphocyte

Stage of B lymphocyte development

1.Stem cell 2. Pro-lymphocyte 3.pre-lymphocyte 4.immature lymphocyte: IgM 5.Mature lymphocyte: IgM และ IgD

Antibody structure

Germline organization of human Ig loci

Variable region of Ig chain

B-cell development in Bone marrow

3.mature naive B cell

2.Immature B-cell

1.pre-B cell:

Stage of lymphocyte maturation

1.Stem cell 2. Pro-lymphocyte 3.pre-lymphocyte 4.immature lymphocyte 5.lymphocyte subsets 6.Mature lymphocyte

Positive and Negative selection

Negative selection

delete T cells whose TCR bind tightly to MHC containing self peptide

Positive selection

retain T cells whose TCR bind to MCH

stage of T lymphocyte development

1.Stem cell 2.Pro-T 3.pre-T 4.Double positive 5.immature T cell 6.Naive mature T cell

Germline organization human TCR loci

Development of T lymphocyte

2type of TCR

Comparison of B & T cell development

similar: B/T cells originate in BM Ag receptor TCR rearagement Negative selective Differences: T cells develop in thymus positive selection required co- receptor expression required(CD4,CD8)

Adaptive immune response

Memory B cell properties

4.Expression of adhesion molecules

3.Cytokine profiles

2.self-renewal

1.anti-apoptosis

type of pathogens

2.Extracellular pathogens

1.Intracellular pathogens

Signals for activation

CD8+ T lymphocyte

CD137(4-1BB): CD70 (D-1BBL)

CD4+ T lymphocyte

cytokine : cytokine receptor

CD40:CD40L

TCR-peptode-MHC complex

Humoral immune response

Effector funtion

Indirect effector function

Phagocytic activity

complement activation

Direct effector function

nutralization

Subtopic

cell-mediated immune response

effector Tc ltmphocyte

CTL-mediated cytotoxicity

effector Th lymphocytes

3.Th17

Epithelial barrier

Nuetrophilic inflammation

2.Th2

Barrier immunity

Activation mast cell

1.Th1

Isotype switching to IgG

Classical macrophage activation

Protactive function

3.Blocking infection

2.activating macrophage

1.Killing infected cells