Development and survival of lymphocyte &Adaptive immune response
Development and survival of lymphocyte
Stage of B lymphocyte development
1.Stem cell
2. Pro-lymphocyte
3.pre-lymphocyte
4.immature lymphocyte: IgM
5.Mature lymphocyte: IgM และ IgD
Antibody structure
Germline organization of human Ig loci
Variable region of Ig chain
B-cell development in Bone marrow
3.mature naive B cell
2.Immature B-cell
1.pre-B cell:
Stage of lymphocyte maturation
1.Stem cell
2. Pro-lymphocyte
3.pre-lymphocyte
4.immature lymphocyte
5.lymphocyte subsets
6.Mature lymphocyte
Positive and Negative selection
Negative selection
delete T cells whose TCR bind
tightly to MHC containing self peptide
Positive selection
retain T cells whose TCR bind to MCH
stage of T lymphocyte development
1.Stem cell
2.Pro-T
3.pre-T
4.Double positive
5.immature T cell
6.Naive mature T cell
Germline organization human TCR loci
Development of T lymphocyte
2type of TCR
Comparison of B & T cell development
similar: B/T cells originate in BM
Ag receptor TCR rearagement
Negative selective
Differences: T cells develop in thymus
positive selection required
co- receptor expression required(CD4,CD8)
Adaptive immune response
Memory B cell properties
4.Expression of adhesion molecules
3.Cytokine profiles
2.self-renewal
1.anti-apoptosis
type of pathogens
2.Extracellular pathogens
1.Intracellular pathogens
Signals for activation
CD8+ T lymphocyte
CD137(4-1BB): CD70 (D-1BBL)
CD4+ T lymphocyte
cytokine : cytokine receptor
CD40:CD40L
TCR-peptode-MHC complex
Humoral immune response
Effector funtion
Indirect effector function
Phagocytic activity
complement activation
Direct effector function
nutralization
Subtopic
cell-mediated immune response
effector Tc ltmphocyte
CTL-mediated cytotoxicity
effector Th lymphocytes
3.Th17
Epithelial barrier
Nuetrophilic inflammation
2.Th2
Barrier immunity
Activation mast cell
1.Th1
Isotype switching to IgG
Classical macrophage activation
Protactive function
3.Blocking infection
2.activating macrophage
1.Killing infected cells
