Категории: Все - epigenética - enfermedad - genes - nutrición

по ROJAS SANCHEZ ROJAS SANCHEZ 3 лет назад

485

Epigenética: Nuevo paradigma de la Salud Pública.

La epigenética representa un nuevo paradigma para la salud pública, centrándose en cómo los factores externos pueden influir en la expresión genética y, por ende, en la salud a lo largo de la vida.

Epigenética: Nuevo paradigma de la Salud Pública.

Where to next?

If after constructing the VMOST tree for your organization you have no open questions, then you can be confident that your organization is well informed and well-aligned around your vision, mission, and strategy.

If you have any open issues from the analysis, then you should resolve these and communicate your vision, mission, and strategy again.

Many organizations have a vision, mission, and objectives but go straight to action, without having a strategy for understanding and solving difficult problems. This is the most likely area for further leadership.

Epigenética: Nuevo paradigma de la Salud Pública.

Type in the name of your organization.

Hipotesis "Variante-común-enfermedad común"
ECNT consecuencia de muchos polimorfismos frecuentes en la población
Estrategias de prevención

Consider replacing strategies that do not solve problems.

Make some notes about how your Strategies should change.

Orientación/Educación
Tx y cuidados paliativos
Cribado (tamizaje)
Dx precoz
Reto para la salud pública

You might need to clarify your objectives to include other strategies, or maybe some of your strategies are not really aligned with objectives and should be changed.

Make some notes about how your objectives or strategies should change.

70% mortalidad mundial (OMS)
"la epidemia invisible"
Enfermedades Crónicas/Complejas No Transmisibles

To deliver this objective, you will need to work strategically.

For any objective, there will be obstacles and problems.

Your strategy should show that you understand the key problems, and know how to solve them.

Example: Establish a high-value exclusive brand to limit competition.

Strategy
Cáncer
Enfermedades mentales
Obesidad y sobrepeso
DM tipo II
Cardíacas
Temple (2016)
Enfoque de política gubernamental más rentable que un enfoque médico
Es prevenible
Add your answer
Hábitos

AQA (agentes químicos ambientales)

Estilo de vida

Medio ambiente

Dieta

Trabajo sinérgico

Salud Pública

Evitar en lugar de curar
2 fases

To execute your strategy, it will break down into a number of tactical activities.
Tactics are practical projects that bring your strategy to life.

Example: Make a list of preferred areas and research the independent food retail outlets in each.

2) Exposición secundaria a vida no saludable
1) Etapa temprana

Futuro

Mejores estrategias terapéuticas
Medidas preventivas desde la gestación

How can you ensure that your staff are making decisions that are influenced by bigger goals?

Make some notes about how you will do this.

Nutrigenómica
Futuras generaciones
Adaptaciones
Transmisión de información
Impacto evolutivo

You might need to ensure that everyone understands your plan.

Make some notes about how you will do this.

Descendencia
Salud del individuo
Prevención, dx temprano y tx

It is not uncommon for those who are working on the tactics of an organization to be unaware of the strategy, objectives, mission, and vision behind them.

Hipótesis DOHaD (1990)

Barker 1980

You might need to review your objectives to ensure that they work as a group and support each other.

Make some notes about how your objectives should change.

"Orígenes fetales de la enfermedad adulta"
Desnutrición fetal

You might need to clarify your mission to embrace other objectives, or maybe your objectives are not really aligned with your real mission.

Make some notes about how your mission statement or objectives should be changed.

+ desarrollo de ECNT
Desórdenes cardíacos y metabólicos
Predicen la salud a futuro
Desarrollo fetal
Dieta primeros 1000 días
Entorno perinatal
Enfermedad

Nutrición excesiva o insuficiente

Factores estresantes

Salud

buenos hábitos

prevención

"Orígenes Evolutivos de la Salud y la Enfermedad"

To deliver your mission, you will need a number of primary objectives.

These are major milestones, showing that you are achieving your mission. These should be written as SMART objectives, which means they are


Example: To partner with 5 new organic food retail outlets this year.

"Reprogramación" Cambiar tx de la vida adulta a la vida temprana antes de que la clínica sea evidente

Epimutaciones

Regulan la expresión de los genes
Silenciamiento
Activación anormal
Permiten prevenir y tratar enfermedades

Make some notes about how your Mission statement could be improved.

"expresión o no expresión de un gen"
Son reversibles

Review your vision statement and mission statement together.

Does your mission statement bring your vision to life? Do the targets in your mission statement align with your vision?

YesNoOther
Permiten intervenciones de prevención y tx
Información del ambiente

In one sentence, summarise your mission.

Your mission states how you express your vision - what you are aiming to do, to make your vision into reality.

Example: to be the leading supplier of organic foods in your area

Influye en el fenotipo y comportamiento

Epigenética

Principales mecanismos
MicroRNAs

74-92% exp. genética

Código de histonas
Metilación

Hipo-activación

Hiper-represión

Expresión o no expresión de los genes
Dependiendo de factores externos
"Estudio de los cambios en la foramción de los genes" (Holliday,2002)

Make some notes about how your vision statement could be improved.

Pueden ser reversibles
"Estudio de interacciones entre genes y sus productos" (Waddington,1942)

Review your Vision statement:

Does your vision really reflect the values and beliefs that motivate you and your staff?

YesNoOther
Modifican expresión fenotípica
Asociada a patogénesis de ECNT

In one sentence, describe the vision of your organization. Your vision should:


Example: You believe that sustainable organic foods are better for people and the environment

ECNT