via MRf(Myogenic regulotory factor
Embryonic Myogenesis
Gastrulation
mesodermal layer
lateral plate mesoderm
paraxial mesoderm
somites
Dermomyotome
Subtopic
myoblast
myocyte
multinucleated muscle fiber
myotome
Hypaxial
epaxial
muscle progenitor cells delamine from the edges of dermomyotome
sclerotomes
vertebrae and ribs
intermediate mesoderm
axial mesoderm
Muscles
Stem cells
Satellite cells
Myoblasts
Dormant stage
Other myoblasts
Myofibres
Muscle fiber
Sarcolemma and basal lamina
Myonuclei in postnatal skeletal muscle tissue
Structure
Epimysium
Perimysium
Endomysium
Single muscle fibers
Myofibril
Sarcomere
Actin fillament
Z disc
I band
H band
A band
Mysosin fillament
protein degradation
transcription factors
NF-kB
inflammatory cytokines
MuRF-1 activity
FOXO
mTOR
protein synthesis
Atrogin-1 activity
muscle atrophy
Protein synthesis
Myostatin-Smad3 pathway
mystatin actavin A
ACVR I/II
Smad 3 activity
negative regulator
Follistation
IGF1-Akt-mTor pathway
IGF-1
Pl3K
Akt
mTOR activity
muscle growth
muscle hypertrophy
positive regulator
