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by Isabella R 4 years ago

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The Nervous System

The Nervous System

The Nervous System

Disorders

Neural + Synaptic Disorders
Alzheimers

caused by large deposits of beta amyloid proteins

starts off slowly + progressively gets worse

general term for memory loss + other intellectual abilities

common cause of dementia

Parkinsons

caused by degeneration of dopamine-releasing neurons in area of midbrain that coordinates muscle movement

affects primarily physical activity

progressive degenerative disorder

Epilepsy

appears during childhood or adolescence

fatigue, stress or flashing lights may trigger seizures

characterized by transient, recurring bouts of abnormal brain cell activity

Brain Tumours
symptoms include headache, vomiting, visual impairment, confusion, muscle weakness + seizures
rising pressure disrupts normal brain function
abnormal growth in or on brain
Infections
Rabies

symptoms include swollen lymph glands, painful swallowing, vomiting, choking, fever + mental derrangement

goes from sensory neurons to brain where it multiplies + kills cells

transmitted by direct contact

infections viral brain disease in mammals

Meningitis

inflammation of meninges b/c of viral or bacterial infection

Encephalitis

symptoms include headache, fever, fatigue, hallucination, confusion, trouble speaking + remembering, + seizures

caused by herpes + HIV

inflammation of brain

brain + spinal cord are spared of most infections because of blood-brain barrier
Trauma
Spinal Cord Injury

injuries to neck cause quadraplegia (legs, arms, trunk)

injuries below neck cause paraplegia (legs + trunk)

impairs sensation + body function below injured area

Concussion

biggest danger is subdural hematoma or hemorrhage

bleeding increases pressure within skull + disrupts function

brief period of unconsciousness where electrical activity of neurons is disrupted

violent blow to head or neck

physical injury to either brain or spinal cord that can be dangerous because brain controls so many functions + spinal cord is pathway to all organs

Memory

Long-Term Memory
memory storage creates additional synapses b/w connecting neurons (makes it easier to activate circuits in the future)
neurons undergo permanent chemical or physical change
if info is important it should be said out loud or written down so info may be transmitted to cerebral cortex for storage in long-term memory centers
Short-Term Memory
remember things for a few seconds or minutes because the neurons that have just fired are easier to fire again in the short term
when receiving new sensory info, stimulus triggers quick bursts of action potentials to limbic system
occurs in limbic system
involves storing info + retrieving it later as needed

Nerves

Spinal Nerves
attaches to spine via dorsal + ventral roots

Ventral Root

motor neurons carry AP away from spinal cord to rest of body

Dorsal Root

sensory neurons transmit incoming AP

13 pairs that connect w/ brain + spinal cord
Cranial Nerves
carry action potentials b/w brain + muscles, glands + receptors of head, neck + thoracic + abdominal cavities
12 pairs in PNS

Hypoglossal

speech + swallowing (tongue muscles)

Accessory

swallowing + movement of head + shoulders

Glossopharyngeal

taste, swallowing, speech + salivation

Vagus

taste, sensations from pharynx, swallowing, coughing, voice, GI tract smooth muscle contraction, heart rate reduction, digestive secretion

Vestibulocochlear

equilibrium + hearing

Facial

taste, facial expressions, tears, salivation + facial sensations

Abducens

Trigeminal

sensations in head, face + jaw, motor control of chewing

Trochlear

movement of eyeball

Oculomotor

movement of eyelid, eyeball, lens, pupil constriction

Optic

vision

Olfactory

sense of smell

consists of axons of many neurons wrapped in tissue coming + going to the same place

Synaptic Transmission

4. Na ions diffuse in + depolarizes postsynaptic membrane in area of synapse
3. neurotransmitter molecules bind to receptors on post synaptic membrane + causes gated channels to open
2. Ca causes vesicles to fuse with presynaptic membrane + release neurotransmitter into synaptic cleft
enters by diffusion b/c synaptic cleft is too narrow
1. action potential arrives at axon bulb, Ca channels in presynaptic membrane open + Ca diffuses into bulb
action potential caused by opening of chemically sensitive ion channels
Synaptic Cleft
fluid filled gap that separates post + presynaptic membranes

Presynaptic membrane is the cell membrane of a neuron that is sending info

Postsynaptic membrane is the cell membrane of a neuron that receives info

muscle cells do not process + integrate info like postsynaptic neurons

too big

muscle cells receive input from 1 neuron (no converging inputs)

Synapse
specialized junction b/w 2 cells

The Sodium-Potassium Pump

Action Potential
Factors Affecting Threshold

whether synaptic connections are excitatory or inhibitory

how many neurons form synapses

stimulus intensity

causes the release of neurotransmitter across synapse
results when sum of all graded potentials is strong enough to reach certain triggering membrane voltage
sudden temporary reversal of voltage difference across cell membrane
Summation
incoming signals from other neurons produce bigger change in membrane potential than one impulse alone
Graded Potentials
Reestablishing Resting Potential

ready for another action potential

potassium channels close

Repolarization

K moves out

makes interior of axon negative again

K channels open

Na channels close

triggered by influx of Na

Depolarization

inside membrane becomes (+) inside

moves voltage closer to 0

Na goes into axon

Na channels open

threshold is exceeded

maintains resting potential
Na + K channels closed to match rate of leakage
Na leaking in + K leaking out balance the rate of leakage
K concentration higher in cytoplasm than interstitial fluid
Na concentration higher in interstitial fluid than in cytoplasm
inside of neuron is (-) compared to outside
-70 mV
3 Na out, 2 K in

Peripheral Nervous System (PNS)

Myelinated Neurons

neurons that have axons wrapped in myelin sheaths

Nodes of Ranvier

uninsulated gaps b/w schwann cells (surface of the axon is exposed)

protected + enclosed by Schwann Cells

produce myelin sheaths around axons

helps regenerate damaged or severed axons in PNS

speeds up transmission of impulses

causes action potentials to jump from node to node fast

saltatory conduction

saves neuron energy

prevents inward leak of Na + outward leak of K

Motor Division (output)
carries info from CNS to other parts of the body

carries signals from CNS to PNS that control internal organs

contains motor neurons carrying info to smooth or cardiac muscle + all other tissue organs EXCEPT skeletal muscle

controls smooth muscle, cardiac muscle + glands

Sympathetic

prepares body for emergencies

releases norepinephrine

provide unified responses

originate in thoracic + lumbar regions of spinal cord

innervate smooth + cardiac muscle, glands, epithelial cells of kidneys + every organ

regulate body functions

function automatically

Parasympathetic

lets your body relax

releases acetylcholine

becomes part of outflow of cranial nerves

originate in brain

Somatic Division

controls voluntary + involuntary skeletal muscle movements

Spinal Reflexes

involuntary responses that are mediated by spinal cord + nerves

4. causes flex of appropriate muscles + lift your foot

called flexor (withdrawal) reflex

3. sensory neurons stimulate interneurons within spinal cord + signals brain + then motor neurons in leg

2. produces action potentials in sensory neurons travelling to spinal cord

1. person steps on sharp objects + activates pain receptors

Sensory Division (input)
carries info to CNS

signals from internal organs

signals from skin, tendons + muscles

signals from external environment

includes components of nervous system outside CNS

Drugs

Psychoactive Drugs
Psychological Dependence

users begin to crave feelings associated with drug or alter their behaviour to obtain it

work by influencing concentrations or actions of neurotransmitters

either bind or affect their release action or reuptake in some way

cocaine blocks reuptake of dopamine

able to cross blood-brain barrier
drugs that affect states of consciousness, emotions or behaviour (alcohol + nicotine)
any substance introduced into body for purpose of causing physiological change

The Brain

Forebrain
Cerebrum

left + right brains connected by corpus callosum

allows hemispheres to share sensory + motor info

inner portion mostly white matter that connects to lower brain areas

Cerebral Cortex

Frontal Lobe

initiates motor activity, speech + thought

most developed lobe

Occipital Lobe

processes visual info

Temporal Lobe

interprets info comprehends written + spoken language + responsible for judgement

Parietal Lobe

primary somatosensory area

primary motor areas initiates motor activity

less sensitive body parts (thigh)

involve fewer neurons + smaller portions

sensitive body parts (lips + genitals)

involve more neurons + larger portions

receives sensory input from skin

gray matter consisting of neurons w/ unmyelinated axons + their associated neuroglial cells

responsible for memory storage, though, conscious awareness + conscious control of muscles

receives, integrates + interprets sensory info from all organs

outer layer of the cerebrum

associated with language, decisions making + conscious thought

most highly developed region of the brain

Limbic System

when different areas are over stimulated we experience strong feelings + emotions

feelings + emotions influence behaviour

describes all neuronal structures that control emotional behaviour + motivational drives

Thalamus

sends signals to the cerebrum

integrates + relays some outgoing motor activity

receives, processes + transfers info

Hypothalamus

regulates homeostasis by monitoring sensory signals

lets us know when we are hungry or thirsty

coordinates functions for pituitary gland

determines complex behaviour (emotions + conscious thought)
Midbrain
controls sleep cycles + wakefulness

Sleep Center

Stages of Sleep

3. Rapid Eye Movement (REM)

when we dream, eyes move rapidly, heart rate, respiration + blood flow to brain increases, + most skeletal muscles go limp to prevent us from responding to our dreams

2. Deep Sleep

muscles relax, heart rate + respiration slow + body temperature falls

1. Wakefulness

steady stream of action potentials get transmitted to cerebrum

group of neurons comprise it + release serotonin that induces sleep by inhibiting neurons that arouse the brain

monitors unconscious movement of skeletal muscles so actions are smooth + coordinated
coordinates movements of head related to vision + hearing
visual + auditory sensory inputs from eyes + ears pass through here before being relayed to high brain
Hindbrain
Pons

aids medulla oblongata in regulating respiration

important in coordinating flow of info b/w cerebellum + high brain

contains group of axons that extend from cerebellum to rest of CNS

connects higher brain to spine

Cerebellum

excessive amounts of alcohol disrupts function

receives input from joint + muscle receptors, balance + position receptors in ear + visual receptors

stores + replicates sequences of skilled events

muscle memories

coordinates basic body movements that are below level of conscious control

Medulla Oblongata

all info going b/w higher areas of brain must go through here

motor nerves from one side of forebrain crosses over to other side of body

right brain controls left body

left brain controls right body

controls coughing, sneezing, vomiting + swallowing

Cardiovascular Center

Respiratory Center

integrates info about blood levels of oxygen + CO2 + adjusts respiration

regulates heart rate + blood pressure

controls vital automatic functions of interval organs

oldest, most primitive brain division
connected to the spinal cord
coordinates basic automatic + vital tasks
receives info in form of action potentials from nerves + spinal cord, integrates info + generates appropriate response
command center of body

Neurotransmitters

Removing Neurotransmitters
may diffuse away from synaptic cleft into general circulation + is destroyed
may be destroyed by enzymes
may be taken back up by presynaptic neuron, repackaged + reused
Inhibitory
hyperpolarize postsynaptic cell + makes it harder for threshold to be reached

makes interior more negative

Somatostatin

inhibits pancreatic release of growth hormone

released in areas of brain + pancreas

Gamma-Aminobutyric Acid

principal inhibitory neurotransmitter in brain

Endorphins

natural opiates that inhibit pain

released in many areas in brain + spinal cord

Dopamine

excitatory or inhibitory depending on the receptors

released in areas of brian + parts of PNS

Serotonin

involved in moods, sleep cycle + appetite

Norepinephrine

plays role in emotions

depedning on receptors can be excitatory or inhibitory

released in areas of the brain, spinal cord + autonomic nervous system

Excitatory
depolarize postsynaptic cell, causing threshold to be exceeded

Glutamate

major excitatory neurotransmitter in the brain

released in areas of brain + spinal cord

Acetylcholine

can be either excitatory or inhibitory on other sites

excitatory on skeletal muscles

released in neuromuscular junctions, autonomic nervous systems + brain

Neurons

main function is to transmit info from one part of the body to the other via electrical impulses
Divergence

action potential from convergence goes to many other neurons

Convergence

neuron receives input from many neurons

Neuroglial Cells
DO NOT make impulses
provide physical support + protection to neurons + help maintain healthy chemical concentrations
Cell Body
Axon

Axon Terminals

ends in an axon bulb

specialized to conduct electrical impulses

slender tube of cell membrane containing a small amount of cytoplasm

Dendrites

sensory neurons connect directly to an axon

axon originates from a dendrite

motor + interneurons have numerous ones that are short + extend in many directions

receive impulses here

axons originate from point of union with cell body

slender extensions that receive info from receptors or incoming impulses from other neurons

contains nucleus, DNA, mitochondria + organelles of the neuron
Motor Neurons
carry nervous systems output to tissues + organs as electrical impulses
transmit impulses away from CNS
Interneurons
receive info from sensory neurons
transmit impulses around CNS
Sensory Neurons
transmit info from PNS to CNS as electrical impulses
specialized to respond to stimulus

Central Nervous System (CNS)

Protection
Blood-Brain Barrier

prevents charged molecules + large objects (proteins, viruses + bacteria) from entering cerebrospinal fluid

Cerebrospinal Fluid

DOES NOT exchange substances

isolates nervous system from infections

fills space b/w arachnoid + pia mater

Meninges

arachnoid (medium)

pia mater (inner)

dura mater (outer)

protected by bone

brain enclosed by skull + spinal cord enclosed by hollow channel

Autonomic Division
2 neurons transmit info to target cells

Preganglionic Cells

cell bodies of first neurons within CNS

Ganglia

lie outside CNS

Postganglionic Neurons

axons extend far reaches of body to communicate w/ internal glads + organs

Oligodendrocytes
produces myelin sheaths

Amyotrophic Lateral Sclerosis

begins in spinal cord in areas involved in motor control of skeletal muscle

Multiple Sclerosis

myelin sheaths in CNS become damaged + form hard scar tissue that cannot allow neuron to transmit impulses

processes, receives, stores + transfers info
consists of brain + spinal cord
Spinal Cord

Grey Matter

sensory + motor neurons synapse w/ CNS

non-myelinated structures near centre of spinal cord

White Matter

myelinated axons on outer portions of spinal cord

serves as superhighway for action potentials traveling b/w brain + rest of body