De-oxygenated RBCs
Dietary Vitamin B12
Co-enzyme in DNA production
Dietary Folic Acid
Nucleic Acid synthesis for DNA
Small Intestine
iron + Apotransferrin
=Transferrin
Stomach
Intrinsic factor
Brenda Mitchell
Heart
Lungs
Oxygenated RBCs
Arterial System
Body Cells
heme converted to bilirubin
Liver
Iron stored as Ferritin
Bone Marrow
Pluripoint stem cells
Proerythroblasts
Multiple divisions
accumulates Hemoglobin
Nucleus lost
Loses mitochondria and ribosomes
Reticulocytes released into circulatory system
Mature Red Blood Cells
Sternum, Pelvis, Vertebrae
Spleen
Recylced Heme from destroyed RBCs
IRON
Old RBCs
Kidney
Erythropoietin
LOW OXYGEN
DIETARY IRON
RED BLOOD CELL LIFE CYCLE
