Diabetes Insipidus

Lab Findings

Low specific gravity

Lower glucose when compared to Diabetes Mellitus

Urine chemistry will be low for electrolytes

Nephrogenic

Normal synthesis of ADH but a defective renal tubular response to ADH.

Causes

Genetic errors in kidney function

Kidney Cysts

Kidney Infection

Cancer

Medications, especially ones containing lithium

Treatment

Low Salt Diet

Microzyde

Confirmatory Testing

Water Deprivation Test

ADH Blood level

MRI

Symptoms

Excessive Thirst

Nocturia

Dilute Urine

Frequent Urination

Constipation

Neurogenic

When synthesis and release of ADH are reduced

Causes

Genetic errors in brain

Brain Injury

Treatment

Mild Symptoms

Increase Water Intake

Severe Symptoms

Desmopressin, hormone that replaces ADH