RESEARCH QUESTION: What is the role of connexin 43 in SKIN wound healing and by what mechanisms does it act upon?
Less of Cx43 increases wound healing capabilities.
Expected Results: Cx43 expressed in normal blood levels. But this is expected to be upregulated wounded models. (Experiment A).
Experiment B with mutants or knockouts of the Cx43 (genetically). Mutants achieved through antisense RNA, siRNA and gap junction block with mimetic peptides. Checking if the effects of lack of connexin43.
Further questions for our research: Is connected Cx43 effected by other connexins in the process of wound healing? What are these other connexins and in what way do they effect Cx43? Connections with N-Cadhein?
