Phagocytes

Phagocytes are also part of the inflammatory response.

Phagocytes are also part of the inflammatory response.

Phagocytes are also part of the inflammatory response.

Phagocytes are also part of the inflammatory response.

In addition, macrophages as well as cells of certain boundary tissues have receptors

In addition, macrophages as well as cells of certain boundary tissues have receptors

that enable them to recognize pathogens, sometimes with great specificity

that enable them to recognize pathogens, sometimes with great specificity

this kind of event will trigger a release of cytokines, which are another type of inflammatory chemical.

What these chemicals do, is they cause local arterioles to dilate

What these chemicals do, is they cause local arterioles to dilate

Chemotaxis will then occur, where phagocytes migrate up the gradient of certain molecules that act as a homing device for the

Chemotaxis will then occur, where phagocytes migrate up the gradient of certain molecules that act as a homing device for the site of injury, ready to eat up any intruders.

The excess of blood in the area causes the redness and swelling that we can visibly see

The excess of blood in the area causes the redness and swelling that we can visibly see

when a part of the body is inflamed. Although this generates pain because of the pressure on nearby nerve endings

when a part of the body is inflamed. Although this generates pain because of the pressure on nearby nerve endings

it is a favorable strategy, because the rush of fluid sweeps any foreign material into lymphatic vessels

it is a
favorable strategy, because the rush of fluid sweeps any foreign material into lymphatic vessels

so that it can be broken down in the lymph nodes, and the fluid also delivers
proteins that are important for clotting to aid in repair.

Once inflammation has initiated, phagocytes then rush the scene, first neutrophils, and then macrophages soon after.

Once inflammation has initiated, phagocytes then rush the scene, first neutrophils, and
then macrophages soon after.

This begins when phagocytes enter the bloodstream from the red bone marrow, so they can get to the injury.

This begins when phagocytes enter the bloodstream from the red bone marrow, so they can get to the injury.

In diapedesis, they squeeze out of the capillary.

In diapedesis, they squeeze out of the capillary.

THE IMMUNE SYSTEM

Innate Defense System

INFLAMMATORY RESPONSE

Phagocytosis:

Is when a cell engulfs some pathogen or other debris, and it sits inside in a vesicle. This vesicle will merge with a lysosome, which has acid hydrolase enzymes that can digest.

These pieces then leave the cell by exocytosis, unable to do any harm. The biggest and best phagocytes are macrophages, which are derived from white blood cells.

It begins with external membranes, like the skin and a variety of mucous membranes.

This separates what’s inside from what’s outside, but of course, there are lots ofways for pathogens to get past this barrier.

Skin: These are very effective at blocking pathogens from entering the body. Is easily get infections when we have cuts on th

Skin: These are very effective at blocking pathogens from entering the body. Is easily get infections when we have cuts on the skin, because pathogens.

Mucosae: They tend to be acidic, which inhibits bacterial growth. Many of them have lysozymes, which destroy bacteria.

Mucosae: They tend to be acidic, which inhibits bacterial growth. Many of them have lysozymes, which destroy bacteria.

Adaptive Defense System

Lymphocytes

Lymphocytes

Originate inside red bone marrow, from hematopoietic stem cells.

A particular antigen, thousands of surface receptors are
produced that are devoted to that recognition.

antibody or lymphocyte

antibody or lymphocyte

these are large proteins, and they consist of four polypeptide chains connected by disulfide bridges.

Some of these are monomers, some are dimers, some are even pentamers, depending on how many antibodies come together.

The two halves of the Y shape are identical. There are two heavy chains, and two light chains, and a hinge region where the kink occurs.

shape depending on which antigen it will recognize, and this region is at the tip of the Y arms, which we call the antigen-bi

shape depending on which antigen it will recognize, and this region is at the tip of the Y arms, which we call the antigen-binding site.

There are five classes of antibody, listed here, where Ig stands for immunoglobulin, another name for antibody, followed by M

There are five classes of antibody, listed here, where Ig stands for immunoglobulin, another name for antibody, followed by M, A, D, G, or E. These have different roles and locations.

These include B lymphocytes or T lymphocytes, depending on what type of immunity they oversee,
and there are also antigen-presenting cells

will bind in a way that resembles enzyme-substrate interactions,and different lymphocytes will recognize different determinants.

These are large Y-shaped proteins that are produced by lymphocytes, and they circulate
in the blood and lymph

pathogens

pathogens

they are able to mark such that phagocytes
can recognize them for destruction

cells

cells

B cells these receptors are actually membrane-bound antibodies

T cells that fail to do this are forced to undergo apoptosis

Kill cells that have been infected
by viruses or vacteria as well as
cancer cells.

MAJOR TYPES

CD4

Activate B cells, Tcells and macrophages

CD8

Destroy foreign cells or body cells with foreign agents

Undergo activation and differentiation
when Tcell antigen receptors interact
with antigen-presenting cells

Co-stimulation must occur from other molecules
on the surface of the antigen-presenting cells

Proliferation and defferentiation

Resulting T cells can be a wild variety

Antigens:

Antigens:

''antibody generating''refers
to any foreign substance that will be recognized as being not of the self, and will thus provoke
an adaptive immune response

These can be proteins, polysaccharides, lipids.

antigenic determinant

antigenic
determinant

The part of the foreign substance that interacts with the immune system

Adaptive Immune System

HUMORAL INMUNE RESPONSE

HUMORAL INMUNE RESPONSE

B cell encounters its antigen

Causes endocytosis

proliferatioan and differentiation
into plasma cells

PRIMARY IMMUNE RESPONSE

PRIMARY IMMUNE RESPONSE

Massive production of antibodies
that recognized the antigen

Artificially

Vaccines

Naturally

Infection